Kinesin-7 CENP-E in tumorigenesis: Chromosome instability, spindle assembly checkpoint, and applications

Kinesin-7 CENP-E in tumorigenesis: Chromosome instability, spindle assembly checkpoint, and applications

Blog Article

Kinesin motors are a large grandpas best family of molecular motors that walk along microtubules to fulfill many roles in intracellular transport, microtubule organization, and chromosome alignment.Kinesin-7 CENP-E (Centromere protein E) is a chromosome scaffold-associated protein that is located in the corona layer of centromeres, which participates in kinetochore-microtubule attachment, chromosome alignment, and spindle assembly checkpoint.Over the past 3 decades, CENP-E has attracted great interest as a promising new mitotic target for cancer therapy and drug development.In this review, we describe expression patterns of CENP-E in multiple tumors and highlight the functions of CENP-E in cancer cell proliferation.

We summarize recent advances in structural domains, roles, and functions of CENP-E in cell division.Notably, we describe the dual functions of CENP-E in inhibiting nightstick twm-850xl and promoting tumorigenesis.We summarize the mechanisms by which CENP-E affects tumorigenesis through chromosome instability and spindle assembly checkpoints.Finally, we overview and summarize the CENP-E-specific inhibitors, mechanisms of drug resistances and their applications.